Michael A Rogawski Selected Research

Cognitive Dysfunction

1/2020	Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial.
12/2019	Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.

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Michael A Rogawski Research Topics

Disease

47	Seizures (Absence Seizure) 11/2023 - 05/2002
36	Epilepsy (Aura) 01/2020 - 01/2002
18	Status Epilepticus (Complex Partial Status Epilepticus) 01/2023 - 01/2009
5	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2003
4	Partial Epilepsies (Epilepsy, Partial) 11/2023 - 11/2007
4	Neuroinflammatory Diseases 12/2021 - 12/2014
4	Temporal Lobe Epilepsy 07/2017 - 08/2002
3	Migraine Disorders (Migraine) 04/2012 - 07/2004
3	Infantile Spasms (West Syndrome) 11/2011 - 01/2002
2	Brain Injuries (Brain Injury) 12/2021 - 04/2014
2	Gliosis 11/2020 - 01/2020
2	Cognitive Dysfunction 01/2020 - 12/2019
2	Epileptic Syndromes 01/2020 - 01/2007
2	Pain (Aches) 01/2015 - 07/2004
2	Drug Resistant Epilepsy 02/2008 - 06/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2007 - 09/2006
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021
1	Disease Progression 01/2021
1	Neurodevelopmental Disorders 01/2018
1	Myoclonus (Nocturnal Myoclonus) 01/2018
1	Rett Syndrome (Rett's Disorder) 01/2018
1	Angelman Syndrome (Syndrome, Angelman) 01/2017
1	Autistic Disorder (Autism) 01/2016
1	Acute Pain 01/2015

Drug/Important Bio-Agent (IBA)

19	Anticonvulsants (Antiepileptic Drugs)IBA 01/2016 - 01/2002
17	NeurosteroidsIBA 01/2023 - 01/2002
16	Pregnanolone (Allopregnanolone)IBA 01/2023 - 07/2004
8	GABA-A Receptors (GABA(A) Receptor)IBA 10/2018 - 07/2004
8	ganaxoloneIBA 10/2018 - 01/2002
7	BenzodiazepinesIBA 01/2023 - 04/2009
7	AMPA Receptors (AMPA Receptor)IBA 01/2021 - 01/2010
7	Pentylenetetrazole (Metrazol)IBA 01/2018 - 06/2005
6	Diazepam (Valium)FDA LinkGeneric 01/2021 - 01/2010
6	perampanelIBA 01/2021 - 03/2011
6	Ionotropic Glutamate ReceptorsIBA 03/2011 - 04/2003
5	Pilocarpine (Ocusert)FDA LinkGeneric 07/2017 - 06/2005
5	gamma-Aminobutyric Acid (GABA)IBA 01/2013 - 01/2002
4	Midazolam (Versed)FDA LinkGeneric 12/2021 - 10/2013
4	tetramethylenedisulfotetramine (DSTA)IBA 12/2021 - 05/2012
4	Kainic Acid (Kainate)IBA 01/2017 - 06/2004
3	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2021 - 06/2004
3	OrganophosphatesIBA 11/2020 - 01/2020
3	Isoflurophate (DFP)FDA Link 11/2020 - 01/2016
3	Sodium Channels (Sodium Channel)IBA 02/2015 - 07/2004
3	Kainic Acid Receptors (Kainate Receptor)IBA 04/2014 - 04/2003
3	Ion Channels (Ion Channel)IBA 05/2013 - 01/2007
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 03/2011 - 01/2003
3	Gluk1 kainate receptorIBA 08/2009 - 04/2003
3	Topiramate (Topamax)FDA LinkGeneric 08/2009 - 04/2003
2	Proteins (Proteins, Gene)FDA Link 12/2021 - 01/2007
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2018
2	AlbuminsIBA 12/2019 - 01/2018
2	Isoflurane FDA LinkGeneric 01/2018 - 09/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2016 - 01/2013
2	PicrotoxinIBA 02/2015 - 05/2002
2	Carbamazepine (Tegretol)FDA LinkGeneric 02/2015 - 06/2004
2	Epoxide HydrolasesIBA 12/2014 - 01/2013
2	AcidsIBA 08/2012 - 08/2009
2	Adrenocorticotropic Hormone (ACTH)FDA Link 11/2011 - 01/2002
2	tetrahydrodeoxycorticosteroneIBA 07/2011 - 05/2002
2	Progesterone FDA LinkGeneric 04/2009 - 03/2003
2	SteroidsIBA 10/2006 - 06/2005
1	XEN1101IBA 11/2023
1	Potassium Channels (Potassium Channel)IBA 11/2023
1	KCNQ3 Potassium ChannelIBA 11/2023
1	pralidoxime (Protopam Chloride)FDA Link 11/2020
1	Nerve AgentsIBA 11/2020
1	Drug CombinationsIBA 11/2020
1	fluoro-jade CIBA 11/2020
1	Atropine FDA LinkGeneric 11/2020
1	Blood Proteins (Serum Proteins)IBA 12/2019
1	Aminobutyrates (Aminobutyric Acid)IBA 10/2018
1	Adenosine (Adenocard)FDA LinkGeneric 01/2018
1	AntibodiesIBA 01/2018
1	Losartan (Cozaar)FDA LinkGeneric 01/2018
1	HMGB1 Protein (HMG1)IBA 01/2018
1	Methyl-CpG-Binding Protein 2IBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2017
1	LigandsIBA 10/2016
1	Neuroprotective AgentsIBA 01/2016
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2016
1	KetonesIBA 01/2016
1	CalciumIBA 08/2015
1	Phenytoin (Dilantin)FDA LinkGeneric 02/2015
1	BicucullineIBA 02/2015
1	Lacosamide FDA Link 02/2015
1	Formaldehyde (Formol)FDA Link 01/2015
1	thiouredopyrenetrisulfonateIBA 12/2014
1	General AnestheticsIBA 12/2014
1	PropionatesIBA 04/2014
1	GluK2 Kainate ReceptorIBA 04/2014

Therapy/Procedure

16	Therapeutics 11/2023 - 06/2002
5	Ketogenic Diet 02/2016 - 09/2006
3	Drug Therapy (Chemotherapy) 01/2016 - 06/2002
2	Aftercare (After-Treatment) 01/2021 - 05/2012
2	Intravenous Infusions 04/2007 - 06/2004
1	Transcranial Magnetic Stimulation 01/2021
1	Topical Administration 01/2018
1	Lasers (Laser) 01/2017
1	Ligation 01/2015